Researchers identify brain circuitry in rodents that may be responsible for negative emotional aspects of pain
A new study has uncovered neuronal circuitry in the brain of rodents that may play an important role in mediating pain-induced anhedonia -- a decrease in motivation to perform reward-driven behaviors. Researchers were able to change the activity of this circuit and restore levels of motivation in a pre-clinical model of pain tested in rodents.
Powerful technique allows scientists to study how proteins change shape inside cells
The scientists' new 'binder-tag' technique allows researchers to pinpoint and track proteins that are in a desired shape or 'conformation,' and to do so in real time inside living cells. The scientists demonstrated the technique in, essentially, movies that track the active version of an important signaling protein -- a molecule, in this case, important for cell growth.