Investigators have injected human stem cells into primate embryos and were able to grow chimeric embryos for a significant period of time -- up to 20 days. The research, despite its ethical concerns, has the potential to provide new insights into developmental biology and evolution. It also has implications for developing new models of human biology and disease.
Genetic ancestry versus race can provide specific targeted insights to predict and treat many diseases
The complex patterns of genetic ancestry uncovered from genomic data in health care systems can provide valuable insights into both genetic and environmental factors underlying many common and rare diseases -- insights that are far more targeted and specific than those derived from traditional ethnic or racial labels like Hispanic or Black, according to researchers.
Treatment not always needed to prevent vision loss in patients with elevated eye pressure
The national Ocular Hypertension Treatment Study was designed to determine whether lowering elevated eye pressure in patients might prevent vision loss from glaucoma. Researchers recently completed follow-up studies on patients 20 years after the start of the original study and found that not all patients with elevated eye pressure need pressure-lowering treatment to prevent vision loss from glaucoma.
Researchers have found that the anti-diabetic drug metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis. Metformin's mechanism is different from existing therapeutics which only treat symptoms, such as the blood pressure drug losartan, so researchers believe that a combination these medications at low dose will be highly beneficial.
New type of cell contributes to increased understanding of ALS
The causes of the serious muscle disease ALS still remain unknown. Now, researchers have examined a type of cell in the brain blood vessels that could explain the unpredictable disease origins and dynamics. The results indicate a hitherto unknown connection between the nervous and vascular systems. The study has potential implications for earlier diagnoses and future treatments.
Those who had COVID-19 may only need one vaccine dose study suggests
Those recovered from COVID-19 had a robust antibody response after the first mRNA vaccine dose, but little immune benefit after the second dose, according to new research. The findings suggest only a single vaccine dose may be needed to produce a sufficient antibody response. Those who did not have COVID-19 did not have a full immune response until after receiving their second vaccine, reinforcing the importance of the two recommended doses.
The brain processes information using both slow and fast currents. Until now, researchers had to use electrodes placed inside the brain in order to measure the latter. Researchers have now successfully visualized these fast brain signals from the outside -- and found a surprising degree of variability.