Some viral diseases could possibly contribute to neurodegeneration. Researchers found that certain viral molecules facilitated intercellular spreading of protein aggregates that are hallmarks of brain diseases like Alzheimer's. These findings may provide clues how acute or chronic viral infections could contribute to neurodegeneration.
Bacterial infections in sinuses of cystic fibrosis patients share surprising similarities
A dogma-challenging discovery reveals that highly adapted bacterial communities in the sinuses of people with cystic fibrosis become more fragmented and experience mutations that erode their genomes. So rather than targeting red herring mutations, researchers suggest paying attention to patterns of genomic adaptation versus erosion, which might better indicate a viable path towards the more effective therapeutics for cystic fibrosis.
COVID-19 vaccination strategies When is one dose better than two
While most of the COVID-19 vaccines are designed as a two-dose regimen, some countries have prioritized vaccinating as many people as possible with a single dose before giving out an additional dose. In a new study, researchers illustrate the conditions under which a "prime first" vaccine campaign is most effective at stopping the spread of the COVID-19 virus. The team found the vaccine waning rate to be a critically important factor in the decision.
Simulation illustrates how COVID-19 social distancing creates pedestrian traffic jams
Researchers examine the dynamics of social distancing practices, common defense against the spread of COVID-19, through the lens of particle-based flow simulations. The study models social distance as the distance at which particles, representing pedestrians, repel fellow particles and sheds light on the relationship between social distancing and pedestrian flow dynamics in corridors by illustrating how adherence to social distancing protocols affects two-way pedestrian movement in a shared space.
Targeted interventions to contain pandemics minimize societal disruption
Nonpharmaceutical interventions, such as isolation, quarantines, and lockdowns, have been implemented in an effort to contain the pandemic, but these are often disruptive and costly. In a new article, researchers identify new and sustainable interventions to contain outbreaks while minimizing the economic and social costs. They built a data-driven mobility model to simulate COVID-19 spreading in Hong Kong, by combining synthetic population, human behavior patterns, and a viral transmission model, and found that by controlling a small percentage of grids, the virus could be largely contained.
New model points to solution to global blood shortage
A mathematical model of the body's interacting physiological and biochemical processes shows that it may be more effective to replace red blood cell transfusion with transfusion of other fluids that are far less in demand.
Researchers fabricate gold nanoparticles with a rapidly decaying radioisotope that can be internalized by cancer cells. Because the radiation remains strongly localized, high doses can be administered without concern for side effects. This research may lead to safer and more effective treatments for many types of cancer.